Many researchers believe that Osteogenesis Imperfecta is an incurable genetic disorder caused solely by defective collagen genes. But is it? Many of the features of OI cannot logically be explained by defective collagen genes alone. If you consider nutrition as a factor in Osteogenesis Imperfecta, then there are logical explanations for many features of the disorder.

If Osteogenesis Imperfecta were really caused solely by a defective collagen gene, then why would a collagen abnormality cause short stature, enlarged foreheads, hyaluronic acid abnormalities, flat nasal bridges, hypercalciuria (excess calcium in the urine) and heavy menstrual bleeding, all of which are common features of Osteogenesis Imperfecta? A defective collagen gene simply does not provide a logical explanation for many of the features we know about the disorder.

Twenty -five percent of all cases of Osteogenesis Imperfecta are sporadic -- there is no family history of the disorder. In some cases, symptoms of OI will come and go throughout a person's life. Wouldn't this be an indication that the disorder is influenced by some environmental triggers, rather than just genes alone?

There are at least 24 nutrients that have been identified to date as being important for bone health. Without research in this area, how do we know that people with Osteogenesis Imperfecta simply don't have high requirements for one or more of these nutrients, or have malabsorption problems that prevent some of these nutrients from being absorbed?

Osteogenesis Imperfecta is currently treated by a wide range of bone building drugs, which are environmental factors. If prescription drugs can alter the course of OI, then isn't is possible that other environmental factors, like diet, could alter the course of OI, too?

If prescription drugs can help OI, are there some prescription drugs that may have contributed to Osteogenesis Imperfecta in the first place, especially in the cases that suddenly popped up when a child reached a certain age?