There is no cure for Osteogenesis Imperfecta, the main purpose of any treatment plan is to improve the quality of life for the patient. Though bone fractures can and will occur, the right preventive measures will keep these to a minimum. In most cases, the methods are nonsurgical and aimed at giving those with Osteogenesis Imperfecta a maximum degree of mobility and independence.

Several medications are being or have been explored for their potential use to treat Osteogenesis Imperfecta.

Bisphosphonates :
Bisphosphonates (BP) particularly those containing nitrogen, are being increasingly administered to increase bone mass and reduce the incidence of fracture. BPs can be dosed orally (e.g. alendronate) or by intravenous injection/infusion.

BP therapy is being used increasingly for the treatment of OI. It has proven efficiency in reducing fracture rates in children, however only a trend towards decreased fracture was seen in a small randomized study in adults. While decreasing fracture rates, there is some concern that prolonged BP treatment may delay the healing of OI fractures, although this has not been conclusively demonstrated.

Pamidronates used in both USA and Canada. Pamidronate given to the child, slow down bone resorption. In children with more-severe Osteogenesis Imperfecta, this treatment often decreases the number of fractures and bone pain.

Pamidronate is administered through an IV, lasting about three hours.. It is mixed with water like substance so that it doesn't burn their veins. The therapy is repeated every three to six months, and lasts for the life of the patient. Many individuals get very sick the first time that it is administered to them.

There are a few side effects of this particular type of medication. Common side effects include bone pain, low calcium levels, nausea, and dizziness. According to recent results, extended periods of pamidrinate, (i.e. 6 years) can actually weaken bones, so patients are recommended to get bone densities every 6 moths-1 year, to monitor bone strength. These medications must be administered by properly trained doctors and require close monitoring.

Currently, doctors are experimenting with other similar medications, as well as human growth hormones and gene therapy.

Calcitonin :
While results have been mixed, studies have shown that results of calcitonin treatment include: decreased annual fracture rate; improved mobility; increased feelings of well-being, and a significant improvement in radiographic bone density.

Growth Hormone :
Growth Hormone can cause a sustained increase in the linear growth rate of children with Osteogenesis Imperfecta, despite the abnormal collagen in their bone matrix. In the first year of treatment, growth hormone responders achieve increased bone formation rate and density, and decreased fracture rates. There is some controversy over the use of growth hormone.

Over-The-Counter Medications :
These pain relievers include aspirin, ibuprofen, and acetaminophen and are very effective at relieving pain. However, complications such as upset stomach or delayed blood clotting time can result from prolonged or excessive use. A doctor should be consulted if you plan on using these drugs continuously for more than two weeks. The doctor can also evaluate how these drugs might interact with any other medications you are currently taking.

Prescription Medications :
A variety of medications can be prescribed to combat pain including other non-steroidal inflammatory medications (NSAIDs), topical ointments, and antidepressants. Antidepressants have been shown to play a role in pain relief by elevating a person's mood. Studies have shown that when depression improves, it can lessen a person's perception of pain.